The Right Vaccine for the Right Pathogen is the Key to Deadly Disease Prevention Success

(Sponsored Content)

Zoetis has done extensive research on bovine respiratory diseases (BRD), such as Mannheimia haemolytica, and how these illnesses cost the industry millions each year. While M. haemolytica is found naturally in the respiratory tract of a cow, without the proper vaccination, it can travel fast and cause sudden or acute pneumonia, often resulting in death within a day’s time. It can be a devastating situation, yet one that can also be prevented. All it takes is the right vaccine for the right pathogen administered at the right time.

From 2011 to 2015, bovine respiratory disease (BRD) in nursing calves cost the beef industry approximately $165 million each year.1 Of the bacterial causes of BRD, M. haemolytica is the most predominant and concerning of the group.2 Animals with an M. haemolytica infection can go from seemingly healthy to deceased in a day’s time.

Prevention starts with understanding how pathogens act
M. haemolytica is found naturally in the respiratory tract of cattle. Dust, stress or viral infections make it easier for the bacteria to travel from the respiratory tract to the lungs. Because of multiple virulence factors, M. haemolytica is an expert at avoiding the animal’s immune defenses and remains tough to clear once an infection occurs.

M. haemolytica typically causes more sudden or acute pneumonia and other BRD bacterial pathogens are commonly secondary invaders causing more chronic pneumonia,” said Jeffrey Sarchet, DVM, Beef Technical Services veterinarian with Zoetis.

M. haemolytica produces leukotoxin, which kills white blood cells and leads to severe lung damage. Enzymatic proteins from the affected white blood cells destroy lung cells, causing lung lesions that produce irreversible, and potentially fatal, damage to cattle. Cattle have an extremely low ratio of lung volume to body size, so any lung damage is detrimental to an animal’s overall health and performance.

“Other bacterial pathogens, like Pasteurella multocida, don’t produce leukotoxin, so they don’t cause the severe acute lung damage that M. haemolytica does,” Dr. Sarchet said.

Protecting against M. haemolytica
M. haemolytica is opportunistic and often strikes when a viral infection has weakened the animal’s immune defenses. Effective control requires vaccines providing viral protection, along with anti-leukotoxin antibodies that help block the effect of leukotoxins and capsular antibodies to increase the ability of white blood cells to engulf and destroy the bacteria.

“One Shot® has proven efficacy for stimulating protection against M. haemolytica and reducing lung lesions,” Dr. Sarchet said. “Unfortunately, vaccines available for other BRD bacterial pathogens, like Pasteurella multocida and Histophilus somnus, have not demonstrated the same efficacy of One Shot based on research from University of Minnesota. Because Pasteurella multocida and Histophilus somnus are also Gram-negative bacteria, adding vaccines to protect against these pathogens can add stress and increase the risk of adverse reactions, so the cost/benefit should be carefully considered.”3

Dr. Sarchet explains that Gram-negative bacteria have endotoxins in the cell wall, which are very potent toxins that cause a stress response in cattle resulting in increased heart and respiratory rate, decreased rumen and intestinal action, fever, vascular shock and possibly death.

“A general rule is to not give an animal more than two or three Gram-negative vaccines at the same time,” Dr. Sarchet said. “Even though blackleg (seven- or eight-way clostridial) vaccines are Gram-positive, we count them as one-half a Gram-negative vaccine. So, for example, if we give One Shot with a seven- or eight-way clostridial vaccine at the same time, it would count as 1½ Gram-negative vaccines. If we add a vaccine to protect against Pasteurella multocida or Histophilus somnus at the same time, it would push the protocol to 2½ to 3½ Gram-negative vaccines, which is a higher risk for the animal.”

Research has shown vaccines with leukotoxoid, like what is found in the One Shot® line of vaccines, can help stimulate effective anti-leukotoxin antibodies against M. haemolytica.4 Surface antigens in One Shot have been proven to stimulate production of antibodies which increase the ability of white blood cells to engulf and destroy M. haemolytica bacteria before it can cause lung damage.4

One Shot has also been shown to decrease the amount and severity of lung lesions in cattle infected with M. haemolytica in organized studies because the adjuvanted leukotoxoid from One Shot helps ensure production of predictably higher antibody levels and more effective M. haemolytica protection.3,4 A comparative study of Zoetis products showed that after 21 days of M. haemolytica exposure, One Shot mitigated 74.5%-79.6% of lesions and prevented 89.4% of mortality within the treatment group.4

“Choosing the right vaccine for the right pathogen is key in helping reduce respiratory disease,” Dr. Sarchet said. “Your herd veterinarian is a great resource to develop a protocol that will prevent problems from Mannheimia haemolytica.”

For more information on respiratory vaccination programs, talk to your local veterinarian or visit or to learn more about solutions offered by Zoetis for combating BRD pathogens.

About Zoetis
Zoetis is the leading animal health company, dedicated to supporting its customers and their businesses. Building on more than 65 years of experience in animal health, Zoetis discovers, develops, manufactures and markets veterinary vaccines, medicines and diagnostics, which are complemented by genetic tests, biodevices and a range of services. Zoetis serves veterinarians, livestock producers and people who raise and care for farm and companion animals with sales of its products in more than 100 countries. In 2018, the company generated annual revenue of $5.8 billion with approximately 10,000 employees. For more information, visit

1 Wang M, Schneider LG, Hubbard KJ, Smith DR. Cost of bovine respiratory disease in preweaned calves on US beef cow/calf operations (2011-2015). JAVMA. 2018;253(5):624-631.
2 Griffin D, Chengappa MM, Kuszak J, McVey DS. Bacterial pathogens of the bovine respiratory disease complex. Vet Clin Food Anim. 2010;26:381-394.
3 Srinand S, Maheswaran SK, Ames TR, Werdin RE, Hsuan SL. Evaluation of three commercial vaccines against experimental bovine pneumonic pasteurellosis. Vet Microbio. 1996;52:81-89.
4 Data on file, Study Report No. 3131W-60-11-843, Zoetis, Inc.



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